The host are fighting to secure a knockout stage spot, while the visitors aim to maintain their perfect European record and secure the top spot.
Match preview
Club Brugge's prospects of securing back-to-back UCL knockout phase appearances are diminishing, especially as they started the round already two points outside the top 24.
Their qualifying hopes have been hindered by a four-match winless streak in the UCL, making it a difficult task.
However, the Belgian side can take solace in the fact that all three of those defeats occurred away from home, as they remain unbeaten at their own ground during this season's league phase.
Compounding their challenge ahead of this fixture against a strong European team, they recently lost 3-2 away to St Truiden at the weekend.
Arsenal, conversely, experienced a setback in their pursuit of a first Premier League title in over two decades at the weekend, as they conceded a goal in stoppage time, resulting in a 2-1 defeat away to Aston Villa.
This loss concluded the Gunners' 18-match competitive unbeaten streak. However, with five of those victories occurring in the UCL, their exceptional form in this competition suggests they could get back to winning ways.
Mikel Arteta's team is on a roll, with their 3-1 win against Bayern Munich last time out being a huge statement. They have now bagged nine straight victories in the UCL group/league phase. If they manage to win in Brugge, they will be only the second English club ever to hit ten consecutive wins.
Club Brugge vs Arsenal head-to-head
This will be the first competitive match between the two clubs, making it unpredictable. Belgian side Club Brugge have struggled against English teams, with only one win, three draws and fourteen defeats in their last eighteen matches.
Meanwhile, Arsenal have a strong record against Belgian opposition, being undefeated in their last nine fixtures, giving them a big edge for this first meeting with Club Brugge.
Club Brugge vs Arsenal team news
Club Brugge will be without several important players for the game. Ludovit Reis remains sidelined through injury, while Lynnt Audoor is also unavailable.
Goalkeeper Nordin Jackers is ruled out as well, forcing the club to rely on alternative options between the posts. Also, Zaid Abner Romero is sidelined with an injury.
Arsenal face an even more lengthy injury list and Mikel Arteta will likely rotate his squad for this game. Cristhian Mosquera joins Gabriel and William Saliba on the treatment table, representing a major blow to the team’s defence.
In the attack, Kai Havertz is unavailable after a setback from his injury. With several starters missing, Arsenal may need to adjust their approach and rely heavily on squad depth to compensate for these notable absences.
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Club Brugge vs Arsenal team probable lineups
Club Brugge (4-2-3-1): Mignolet; Siquet, Ordoñez, Mechele, Seys; Stankovic, Onyedika; Forbs, Vanaken, Tzolis; Vermant
Arsenal (4-2-3-1): Kepa; Timber, White, Hincapié, Calafiori; Norgaard, Merino, Nwaneri; Martinelli, Gyokeres, Madueke
Club Brugge vs Arsenal prediction and betting tips
Despite Arsenal’s significant injury problems, their superior attacking quality and push to secure the top spot should see them through.
Club Brugge's poor defensive form in Europe makes it difficult to back them, even at home. We predict a comfortable win for the English side.
Prediction
- Club Brugge 1-3 Arsenal
- Full-time result: Arsenal Win
- Both teams to score – Yes
- Over 2.5 goals