This London derby features two teams that needed stoppage time goals to avoid defeat in their last outing.
Chelsea snatched a 1-1 draw at Manchester City, while the Cottagers fought back to hold Liverpool 2-2.
Fulham vs Chelsea: Match Preview
Chelsea's Under-21s coach Calum McFarlane, who was thrust into the spotlight after Enzo Maresca's departure, oversaw a spirited performance against Manchester City.
While the point at the Etihad was a significant achievement, it extended Chelsea's winless streak in the league to four matches.
Victory on Wednesday, coupled with their superior goal difference, could see the Blues climb back into the top four, potentially under the guidance of new manager Liam Rosenior, who is reportedly close to being appointed.
Fulham also experienced late drama in their recent fixture. After Cody Gakpo seemed to have secured a win for Liverpool, the Dutchman's celebration was cut short in spectacular fashion. In the 97th minute, substitute Harrison Reed, with one of only three touches in his brief cameo, unleashed an astonishing long-range effort to level the scores at 2-2.
That incredible goal extended Fulham's unbeaten run in the Premier League to five games, a spell in which they have collected 11 out of a possible 15 points. Marco Silva's side now sits 11th, just three points behind Chelsea, and another positive result would thrust them firmly into the European qualification picture.
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Fulham vs Chelsea: Head-to-head
Despite their strong form, history is not on Fulham's side in this fixture. They have lost four of their last five encounters with Chelsea, including a 2-0 defeat at Stamford Bridge in August, and have only managed three wins against their rivals in the Premier League era.
Fulham vs Chelsea: Team News
Chelsea will be boosted by the return of Moises Caicedo, who missed the Manchester City game through suspension.
The Blues are still without Dario Essugo, Levi Colwill, and Romeo Lavia.
For Fulham, the AFCON trio of Chukwueze, Bassey, and Iwobi remain on international duty with Nigeria. Rodrigo Muniz is out with a thigh injury, while Kenny Tete (hamstring), Joshua King (knee), and Ryan Sessegnon (hamstring) are all doubtful.
Fulham vs Chelsea: Possible Lineups
Fulham 4-2-3-1: Leno; Cuenca, Andersen, Diop; Castagne, Berge, Lukic, Robinson; Wilson, Kevin; Jimenez
Chelsea 4-2-3-1: Jorgensen; James, Chalobah, Badiashile, Gusto; Caicedo, Fernandez; Estevao, Pedro, Neto; Delap
Fulham vs Chelsea: Prediction & Betting Tips
Fulham have found some fun at the right time, and are notoriously tough to beat at home. Caicedo's return should make Chelsea stronger, and we expect these two sides to cancel each other out.
After reading this preview, head straight to LiveScore Bet to enjoy the best odds on the market.
Over 2.5 goals
Both teams to score
Harry Wilson to score anytime