Manchester United vs Chelsea odds, team news, lineup and prediction

Manchester United host Chelsea in a crucial Premier League clash at Old Trafford, with the teams experiencing contrasting fortunes.

United sit 14th with just one win in five matches, while Chelsea occupy 5th place despite their midweek Champions League defeat.

The Blues have dominated recent meetings, winning three of the last five encounters. Both sides will field strong lineups despite injury concerns, with star players Bruno Fernandes and Cole Palmer expected to be influential.

Match preview

Manchester United will host Chelsea in a highly anticipated Premier League clash at Old Trafford on September 20, 2025, at 17:30.

This Round 5 fixture will be officiated by referee Peter Bankes as both teams look to improve their early-season standings.

The Red Devils, currently sitting 14th with just 4 points from their opening four matches, face a Chelsea side that has made a stronger start to the campaign, occupying 5th place with 8 points and showing impressive attacking form with 9 goals scored.

Manchester United vs Chelsea: possible lineups

Manchester United (3-4-2-1, Ruben Amorim)
Goalkeeper: Altay Bayindir (1)
Defence: Leny Yoro (15), Matthijs de Ligt (4), Luke Shaw (23)
Midfield: Noussair Mazraoui (3), Casemiro (18), Manuel Ugarte (25), Patrick Dorgu (13), Bryan Mbeumo (19), Bruno Fernandes (8)
Forward: Benjamin Sesko (30)
Absent: Mason Mount (7), Matheus Cunha (10), Diogo Dalot (2), Lisandro Martinez (6)

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Chelsea (4-1-4-1, Enzo Maresca)
Goalkeeper: Robert Sanchez (1)
Defence: Malo Gusto (27), Trevoh Chalobah (23), Tosin Adarabioyo (4), Marc Cucurella (3)
Midfield: Moises Caicedo (25), Estevao (41), Enzo Fernandez (8), Cole Palmer (10), Pedro Neto (7)
Forward: Joao Pedro (20)
Absent: Levi Colwill (6), Dario Essugo (14), Liam Delap (9)
Doubtful: Benoit Badiashile (5), Romeo Lavia (45)
Unavailable: Mykhaylo Mudryk

Most recent head-to-head

The recent history between these two Premier League giants has been closely contested, with Chelsea holding a slight edge in their last five meetings.

The Blues have won three of those encounters, including their most recent clash at Stamford Bridge in May 2025, where Marc Cucurella's 71st-minute strike secured a 1-0 victory.

Manchester United claimed one win during this period, a convincing 4-1 home triumph in May 2023, while the teams also shared a 1-1 draw at Old Trafford in November 2024.

Their meetings have typically been high-scoring affairs, with Cole Palmer and Scott McTominay proving particularly influential goal scorers in recent fixtures.

Manchester United preview

Manchester United enter this fixture in concerning form, having collected just one win from their last five matches across all competitions.

Their most recent outing ended in a comprehensive 3-0 defeat to Manchester City on September 14, following a hard-fought 3-2 victory over Burnley on August 30, where Bryan Mbeumo found the net.

The Red Devils were held to a 2-2 draw by lower-league Grimsby in the EFL Cup on August 27 and managed only a 1-1 draw at Fulham on August 24. Their season began with a narrow 0-1 home loss to Arsenal on August 17.

Chelsea preview

Chelsea, meanwhile, have shown more consistency despite a recent 3-1 defeat to Bayern Munich in the Champions League on September 17.

In the Premier League, they drew 2-2 with Brentford on September 13 after consecutive victories – a 2-0 win against Fulham on August 30 and an impressive 5-1 thrashing of West Ham on August 22.

Their campaign began with a goalless draw against Crystal Palace on August 17, but they have since improved.